How does sacubitril + valsartan enhance the effects of natriuretic peptides?

Sacubitril + valsartan enhances natriuretic peptide effects through sacubitril’s active metabolite LBQ657, which inhibits neprilysin and reduces peptide degradation, enhancing signalling through guanylyl cyclase-coupled receptors that increases cyclic guanosine monophosphate (cGMP).