Answer
Riociguat sensitises soluble guanylate cyclase (sGC) to nitric oxide (NO) by stabilising NO–sGC binding and also directly stimulates sGC independently of NO, increasing cyclic guanosine monophosphate (cGMP) generation.
Sources for this answer
- Adempas 0.5 mg, 1.0 mg, 1.5 mg, 2.0 mg, 2.5 mg film-coated tabletsMerck Sharp & Dohme (UK) Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 16Document updated
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