Answer
Ketoconazole 400 mg once daily increased riociguat mean AUC by 150% (range up to 370%) and mean Cmax by 46%, prolonged terminal half-life from 7.3 to 9.2 hours and reduced total body clearance from 6.1 to 2.4 L/h.
Sources for this answer
- Adempas 0.5 mg, 1.0 mg, 1.5 mg, 2.0 mg, 2.5 mg film-coated tabletsMerck Sharp & Dohme (UK) Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 16Document updated
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