Answer
Pamidronate disodium inhibits bone breakdown by osteoclasts, apparently mainly through a local, direct effect when bound to bone mineral, and also suppresses osteoclast precursors from reaching bone.
Sources for this answer
- Pamidronate Disodium 9 mg/ml Sterile ConcentrateHospira UK Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 10Document updated
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