Answer
In healthy subjects, a single 100 mg midostaurin dose given with a single rosuvastatin dose increased rosuvastatin AUCinf by 37%, AUClast by 48%, and peak concentration (Cmax) approximately twofold (2.01 times) compared with rosuvastatin alone.
Sources for this answer
- Rydapt 25 mg soft capsulesNovartis Pharmaceuticals UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 10Document updated
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