Answer
In 36 healthy subjects, ketoconazole at steady state increased peak midostaurin concentration (Cmax) 1.8-fold and overall exposure (AUCinf) 10-fold after a single 50 mg midostaurin dose.
Sources for this answer
- Rydapt 25 mg soft capsulesNovartis Pharmaceuticals UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 10Document updated
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