Answer
Methotrexate inhibits folic acid reduction and cell proliferation, acting mainly during the S-phase of cell mitosis in actively proliferating tissues; cellular uptake uses active reduced-folate transport, and polyglutamation prolongs its intracellular cytotoxic effect.
Sources for this answer
- Methotrexate 2mg/ml Oral SolutionRosemont Pharmaceuticals Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 15Document updated
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