letermovir · Medicine question

How does letermovir inhibit cytomegalovirus replication?

iatroX medicinesPublished 8 November 2026

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Letermovir inhibits the cytomegalovirus DNA terminase complex required for cleavage and packaging of viral progeny DNA, disrupting formation of proper unit-length genomes and interfering with virion maturation.

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PREVYMIS 240 mg film-coated tabletsMerck Sharp & Dohme (UK) Limited · emc · SmPC §5.1 Pharmacodynamic properties · Version 14Document updated 10 February 2026

Sources checked 8 November 2026

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