Answer
Letermovir significantly decreases voriconazole plasma concentrations through CYP2C19 induction, with a less pronounced effect expected for oral letermovir without ciclosporin than for intravenous letermovir with or without ciclosporin or oral letermovir with ciclosporin.
Sources for this answer
- PREVYMIS 240 mg film-coated tabletsMerck Sharp & Dohme (UK) Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 14Document updated
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