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Medicines ivacaftorQuestion & answer

ivacaftor · Medicine question

How does ketoconazole affect ivacaftor exposure?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Co-administration with ketoconazole, a strong CYP3A inhibitor, increased ivacaftor exposure (AUC) 8.5-fold.

Sources for this answer

Kalydeco 150 mg film-coated tabletsVertex Pharmaceuticals (Europe) Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 35Document updated 14 July 2026

Sources checked 8 November 2026

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ivacaftor

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