Answer
In adults, a single 125 mg aprepitant dose on day 5 of ketoconazole 400 mg daily for 10 days increased aprepitant exposure (AUC) approximately fivefold and its mean terminal half-life approximately threefold.
Sources for this answer
- EMEND 80mg, 125mg hard CapsulesMerck Sharp & Dohme (UK) Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 22Document updated
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