Answer
Abacavir + lamivudine are converted inside cells to active triphosphates that competitively inhibit HIV reverse transcriptase, with their main antiviral action occurring through incorporation into viral DNA and consequent DNA chain termination.
Sources for this answer
- Abacavir/Lamivudine Dr. Reddy's 600 mg/300 mg Film-Coated TabletsDr. Reddy's Laboratories (UK) Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 4Document updated
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