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Medicines topiramateQuestion & answer

topiramate · Medicine question

How can topiramate affect INR in patients taking warfarin?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Decreased INR has been reported in patients taking topiramate with warfarin, so INR should be carefully monitored during concomitant treatment.

Sources for this answer

Topamax 25 mg TabletsJanssen-Cilag Ltd (a Johnson & Johnson Company) · emc · SmPC §4.5 Interaction with other medicinal products · Version 45Document updated 3 July 2024

Sources checked 8 November 2026

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