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Medicines topiramateQuestion & answer

topiramate · Medicine question

How can topiramate cause metabolic acidosis?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Topiramate inhibits renal carbonic anhydrase, lowering serum bicarbonate and potentially causing hyperchloremic, non-anion gap metabolic acidosis.

Sources for this answer

Topamax 25 mg TabletsJanssen-Cilag Ltd (a Johnson & Johnson Company) · emc · SmPC §4.4 Special warnings and precautions for use · Version 45Document updated 3 July 2024

Sources checked 8 November 2026

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