hydrochlorothiazide + lisinopril · Medicine question

How can the hydrochlorothiazide component of Zestoretic affect uric acid levels and gout?

Name: How can the hydrochlorothiazide component of Zestoretic affect uric acid levels and gout?
Published: 2026-11-08T01:53:13.240Z

iatroX medicinesPublished 8 November 2026

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Hydrochlorothiazide in Zestoretic may cause hyperuricaemia and/or gout in certain patients, although lisinopril may increase urinary uric acid excretion and thereby lessen hydrochlorothiazide’s hyperuricaemic effect.

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Zestoretic 20Atnahs Pharma UK Ltd · emc · SmPC §4.4 Special warnings and precautions for use · Version 23Document updated 3 February 2025

Sources checked 8 November 2026

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