methotrexate · Medicine question

How can omeprazole interact with high-dose methotrexate?

iatroX medicinesPublished 8 November 2026

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Omeprazole used with high-dose methotrexate may elevate and prolong serum levels of methotrexate and/or its metabolite hydroxymethotrexate, potentially causing methotrexate toxicity, so caution is required.

Sources for this answer

Methotrexate 25 mg/ml InjectionHospira UK Ltd · emc · SmPC §4.4 Special warnings and precautions for use · Version 27Document updated 10 July 2026

Sources checked 8 November 2026

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