Answer
Chemotherapy combinations containing vinblastine sulfate may reduce phenytoin blood levels and increase seizure activity; although vinblastine’s contribution is unestablished, phenytoin dosage adjustment based on serial blood-level monitoring may be needed.
Sources for this answer
- Vinblastine Sulfate 1 mg/ml InjectionHospira UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 18Document updated
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