Does taking Vipdomet with food change total exposure to alogliptin or metformin?

Taking Vipdomet with food does not change total exposure (AUC) to alogliptin or metformin, although peak concentrations decrease by 13% and 28%, respectively, and metformin’s peak is delayed by 1.5 hours; these changes are unlikely to be clinically significant, and Vipdomet should be taken with meals to reduce metformin-related gastrointestinal effects.