Answer
Alogliptin/metformin should not be used during pregnancy because there are no data in pregnant women, and combination studies in pregnant rats showed reproductive toxicity at approximately 5–20 times human exposure at the recommended dose, for metformin and alogliptin respectively.
Sources for this answer
- Alogliptin/Metformin Hydrochloride 12.5 mg/1000 mg film-coated tabletsTakeda UK Ltd · emc · SmPC §4.6 Fertility, pregnancy and lactation · Version 12Document updated
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