Answer
Yes, rhabdomyolysis has been reported with trametinib dimethyl sulfoxide alone or with dabrafenib; severe cases required hospitalisation, treatment interruption or permanent discontinuation, and signs or symptoms warrant clinical evaluation and treatment as indicated.
Sources for this answer
- Mekinist film-coated tabletsNovartis Pharmaceuticals UK Ltd · emc · SmPC §4.4 Special warnings and precautions for use · Version 29Document updated
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