Answer
Yes. Tenofovir disoproxil can cause renal impairment and renal-tubule injury. Cobicistat can also raise serum creatinine without reducing glomerular function, so results require clinical interpretation.
Sources for this answer
- Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Disoproxil Gilead150 mg/150 mg/200 mg/245 mg film-coated tablets — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.