Answer
Tenofovir disoproxil can reduce bone mineral density, and renal-tubule injury can rarely cause bone softening, pain or fractures.
Sources for this answer
- Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Disoproxil Gilead150 mg/150 mg/200 mg/245 mg film-coated tablets — Current selected SmPCemc · Summary of Product Characteristics
General medicine information. Follow the instructions for your own medicine and speak to a pharmacist or clinician about your individual circumstances.