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Medicines selpercatinibQuestion & answer

selpercatinib · Medicine question

Why should St John's wort be avoided with selpercatinib?

iatroX medicinesPublished 8 November 2026

The answer

Answer

St John's wort should be avoided with selpercatinib because it is a strong CYP3A4 inducer that may decrease selpercatinib plasma concentrations.

Sources for this answer

Retsevmo 40mg and 80mg film-coated tabletsEli Lilly and Company Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 3Document updated 5 September 2026

Sources checked 8 November 2026

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selpercatinib

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