Answer
Itraconazole, a strong CYP3A inhibitor, increased selpercatinib peak plasma concentration (Cmax) by 30% and overall exposure (AUC) by 130% when co-administered with a single 160 mg selpercatinib dose, compared with selpercatinib alone.
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- Retsevmo 40mg and 80mg film-coated tabletsEli Lilly and Company Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 3Document updated
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