Answer
Rifampicin should be avoided with gilteritinib fumarate because it strongly induces CYP3A/P-gp and decreases gilteritinib plasma concentrations; in healthy subjects, rifampicin 600 mg at steady state reduced mean peak concentration by 27% and total exposure by 70% after a single 20 mg gilteritinib dose.
Sources for this answer
- Gilteritinib Astellas 40 mg film-coated tabletsAstellas Pharma Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 7Document updated
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