How can gilteritinib fumarate affect antidepressants such as escitalopram, fluoxetine and sertraline?

Based on in vitro data, gilteritinib fumarate may reduce the effects of antidepressants such as escitalopram, fluoxetine and sertraline that target 5HT2B or sigma nonspecific receptors, so concomitant use should be avoided unless essential for patient care.