Answer
Ranolazine (Ranexa) should not be used with St John's wort because it induces CYP3A4, and co-administration with CYP3A4 inducers is expected to cause lack of efficacy.
Sources for this answer
- Ranexa 375 mg Prolonged-release tabletA. Menarini Farmaceutica Internazionale SRL · emc · SmPC §4.4 Special warnings and precautions for use · Version 20Document updated
Sources checked