ranolazine · Medicine question

How does ranolazine affect digoxin blood levels?

iatroX medicinesPublished 8 November 2026

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Ranolazine (Ranexa) has been reported to increase digoxin blood concentrations by an average of 1.5-fold when taken together, so digoxin levels should be monitored when Ranexa treatment is started or stopped.

Sources for this answer

Ranexa 375 mg Prolonged-release tabletA. Menarini Farmaceutica Internazionale SRL · emc · SmPC §4.5 Interaction with other medicinal products · Version 20Document updated 21 April 2023

Sources checked 8 November 2026

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