Answer
Proton pump inhibitors such as rabeprazole should be avoided with dacomitinib monohydrate (Vizimpro) because dacomitinib has greater solubility at acidic pH, and rabeprazole reduced its peak concentration and overall exposure.
Sources for this answer
- Vizimpro 15mg film-coated tabletsPfizer Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 5Document updated
Sources checked