nilotinib · Medicine question

Why should nilotinib not be taken with rifampicin?

iatroX medicinesPublished 8 November 2026

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Answer

Nilotinib should not be taken with rifampicin because rifampicin strongly induces CYP3A4, reducing nilotinib’s peak concentration (Cmax) by 64% and overall exposure (AUC) by 80%.

Sources for this answer

Nilotinib 150mg Hard CapsulesZentiva · emc · SmPC §4.5 Interaction with other medicinal products · Version 2Document updated 6 January 2026

Sources checked 8 November 2026

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