Answer
Dacarbazine and fotemustine should not be used concomitantly because their combined use can cause acute pulmonary toxicity, specifically adult respiratory distress syndrome, which may be fatal.
Sources for this answer
- Dacarbazine 100mg, 200mg, 500mg, 1000mgmedac Pharma LLP · emc · SmPC §4.5 Interaction with other medicinal products · Version 12Document updated
Sources checked