Answer
Dacarbazine inhibits DNA synthesis and cell growth independently of the cell cycle; it is considered inactive against tumours itself but is rapidly converted by microsomal N-demethylation to 5-amino-imidazole-4-carboxamide and a methyl cation responsible for its alkylating effect.
Sources for this answer
- Dacarbazine 100mg, 200mg, 500mg, 1000mgmedac Pharma LLP · emc · SmPC §5.1 Pharmacodynamic properties · Version 12Document updated
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