Answer
Ciclosporin inhibits hepatic uptake and hepatobiliary secretion of bile acids and cholesterol 7α-hydroxylase, altering cholic acid pharmacokinetics and pharmacodynamics; if coadministration is necessary, serum and urine bile acids require close monitoring and the cholic acid dose adjustment.
Sources for this answer
- Orphacol 50 milligram capsules and 250 milligram capsulesTHERAVIA · emc · SmPC §4.5 Interaction with other medicinal products · Version 8Document updated
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