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Medicines cholic acidQuestion & answer

cholic acid · Medicine question

Has severe liver toxicity been reported with cholic acid?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Yes, severe liver toxicity, including cases with fatal outcomes, has been reported with cholic acid use.

Sources for this answer

Orphacol 50 milligram capsules and 250 milligram capsulesTHERAVIA · emc · SmPC §4.4 Special warnings and precautions for use · Version 8Document updated 14 January 2025

Sources checked 8 November 2026

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More questions about cholic acid

Have gallstones been reported during long-term treatment with cholic acid?Can Orphacol (cholic acid) capsules be opened for infants and children who cannot swallow them?Does cholic acid affect the ability to drive or use machines?How do cholestyramine, colestipol, colesevelam and aluminium hydroxide affect cholic acid?How does Orphacol (cholic acid) work in inherited primary bile acid synthesis disorders?How does ursodeoxycholic acid interfere with the action of cholic acid?

cholic acid

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