Answer
Taking rivaroxaban with systemic ketoconazole is not recommended because ketoconazole strongly inhibits both CYP3A4 and P-gp, increasing rivaroxaban exposure and anticoagulant effects, which may increase bleeding risk.
Sources for this answer
- Xarelto 10 mg film-coated tabletsBayer plc · emc · SmPC §4.5 Interaction with other medicinal products · Version 36Document updated
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