Is rivaroxaban recommended for patients with antiphospholipid syndrome and a history of thrombosis?

Rivaroxaban is not recommended for patients with antiphospholipid syndrome and a history of thrombosis, particularly those triple-positive for lupus anticoagulant, anticardiolipin and anti-beta 2-glycoprotein I antibodies, because DOAC treatment may increase recurrent thrombotic events compared with vitamin K antagonist therapy.