Answer
Taking Kivexa with cladribine is not recommended because lamivudine inhibits cladribine’s intracellular phosphorylation in vitro, potentially reducing cladribine’s efficacy in clinical use, with some clinical findings also supporting a possible interaction.
Sources for this answer
- Kivexa 600 mg/300 mg film-coated tabletsViiV Healthcare UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 43Document updated
Sources checked