doravirine · Medicine question

Why is taking doravirine with rifampicin contraindicated?

iatroX medicinesPublished 8 November 2026

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Taking doravirine with rifampicin is contraindicated because rifampicin is a strong CYP3A enzyme inducer expected to significantly decrease doravirine plasma concentrations, potentially reducing Pifeltro's effectiveness.

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Pifeltro 100 mg film-coated tabletsMerck Sharp & Dohme (UK) Limited · emc · SmPC §4.3 Contraindications · Version 14Document updated 14 January 2026

Sources checked 8 November 2026

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