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Medicines doravirineQuestion & answer

doravirine · Medicine question

How does rifabutin affect doravirine concentrations?

iatroX medicinesPublished 8 November 2026

The answer

Answer

Rifabutin, a moderate CYP3A inducer, decreases doravirine concentrations when co-administered.

Sources for this answer

Pifeltro 100 mg film-coated tabletsMerck Sharp & Dohme (UK) Limited · emc · SmPC §4.5 Interaction with other medicinal products · Version 14Document updated 14 January 2026

Sources checked 8 November 2026

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doravirine

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What monitoring is recommended when doravirine is taken with tacrolimus or sirolimus?Which enzyme primarily metabolises doravirine?How much lactose does each Pifeltro (doravirine) tablet contain?What do Pifeltro (doravirine) 100 mg film-coated tablets look like?Which severe skin reactions have been reported with doravirine-containing regimens?Who is Pifeltro (doravirine) indicated to treat?

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