Answer
Taking bosentan with cyclosporine A is contraindicated because co-administration increased initial bosentan trough concentrations approximately 30-fold and steady-state concentrations 3–4-fold, while decreasing cyclosporine A blood concentrations by approximately 50%.
Sources for this answer
- Bosentan Milpharm 125 mg film-coated tabletsAurobindo Pharma - Milpharm Ltd. · emc · SmPC §4.5 Interaction with other medicinal products · Version 10Document updated
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