Answer
In nine healthy subjects taking bosentan 125 mg twice daily with rifampicin for seven days, bosentan plasma concentrations decreased by 58%, with an almost 90% decrease in an individual case; concomitant use is not recommended.
Sources for this answer
- Bosentan Milpharm 125 mg film-coated tabletsAurobindo Pharma - Milpharm Ltd. · emc · SmPC §4.5 Interaction with other medicinal products · Version 10Document updated
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