Answer
St John's wort is contraindicated with Sofosbuvir/Velpatasvir/Voxilaprevir Gilead because strong induction of P-gp and/or CYP enzymes may lower sofosbuvir, velpatasvir and/or voxilaprevir plasma concentrations, reducing the treatment's therapeutic effect.
Sources for this answer
- Sofosbuvir/Velpatasvir/Voxilaprevir Gilead 400/100/100 mg Film-coated tabletGilead Sciences Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 18Document updated
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