sofosbuvir + velpatasvir + voxilaprevir · Medicine question

How does the active metabolite of the sofosbuvir component in sofosbuvir + velpatasvir + voxilaprevir stop hepatitis C viral RNA synthesis?

iatroX medicinesPublished 8 November 2026

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In sofosbuvir + velpatasvir + voxilaprevir, sofosbuvir is metabolised intracellularly to the active uridine analogue triphosphate GS-461203, which the hepatitis C virus NS5B polymerase incorporates into viral RNA, where it acts as a chain terminator to stop RNA synthesis.

Sources for this answer

Sofosbuvir/Velpatasvir/Voxilaprevir Gilead 400/100/100 mg Film-coated tabletGilead Sciences Ltd · emc · SmPC §5.1 Pharmacodynamic properties · Version 18Document updated 18 June 2025

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