Answer
Rifampicin is contraindicated with Paxlovid because induction of its CYP3A4 metabolic pathway may decrease nirmatrelvir/ritonavir plasma concentrations, potentially causing loss of virologic response and possible resistance.
Sources for this answer
- Paxlovid 150 mg/100 mg film-coated tabletsPfizer Limited · emc · SmPC §4.3 Contraindications · Version 12Document updated
Sources checked