Answer
Oral midazolam is contraindicated with Paxlovid because Paxlovid inhibits its CYP3A4 metabolic pathway, increasing midazolam plasma concentrations and the risk of extreme sedation and respiratory depression.
Sources for this answer
- Paxlovid 150 mg/100 mg film-coated tabletsPfizer Limited · emc · SmPC §4.3 Contraindications · Version 12Document updated
Sources checked