ramipril · Medicine question

Why is ramipril contraindicated with sacubitril/valsartan?

iatroX medicinesPublished 8 November 2026

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Ramipril is contraindicated with sacubitril/valsartan because concomitant use increases angioedema risk; at least 36 hours must elapse after the last dose of either medicine before starting the other.

Sources for this answer

Ramipril Aurobindo 5 mg TabletsAurobindo Pharma - Milpharm Ltd. · emc · SmPC §4.5 Interaction with other medicinal products · Version 9Document updated 15 July 2026

Sources checked 8 November 2026

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