naloxegol oxalate · Medicine question

Why is naloxegol not recommended with rifampin?

iatroX medicinesPublished 8 November 2026

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Naloxegol is not recommended with rifampin, a strong CYP3A4 inducer, because co-administration reduced naloxegol exposure (AUC) by 89% and peak concentration (Cmax) by 76% compared with naloxegol alone.

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Moventig 25mg film-coated tabletsGrunenthal Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 14Document updated 1 April 2026

Sources checked 8 November 2026

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