Answer
Lithium is not recommended with hydrochlorothiazide + lisinopril because these medicines reduce renal lithium clearance, increasing serum lithium concentrations and posing a high risk of toxicity; if the combination proves necessary, serum lithium levels require careful monitoring.
Sources for this answer
- Zestoretic 20Atnahs Pharma UK Ltd · emc · SmPC §4.5 Interaction with other medicinal products · Version 23Document updated
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