efavirenz · Medicine question

Why is efavirenz contraindicated with elbasvir/grazoprevir?

iatroX medicinesPublished 8 November 2026

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Efavirenz is contraindicated with elbasvir/grazoprevir because CYP3A4 induction significantly decreases elbasvir and grazoprevir plasma concentrations, potentially causing loss of virologic response.

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Efavirenz 600 mg film-coated tabletsAurobindo Pharma - Milpharm Ltd. · emc · SmPC §4.5 Interaction with other medicinal products · Version 12Document updated 21 May 2026

Sources checked 8 November 2026

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