Answer
Co-administration of efavirenz with sofosbuvir/velpatasvir is not recommended because efavirenz induces CYP3A and CYP2B6, reducing systemic exposure to velpatasvir by approximately 50%.
Sources for this answer
- Efavirenz 600 mg film-coated tabletsAurobindo Pharma - Milpharm Ltd. · emc · SmPC §4.5 Interaction with other medicinal products · Version 12Document updated
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